Mitochondrial Toxicity
نویسندگان
چکیده
منابع مشابه
Mitochondrial Toxicity
Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many genetic differences leading to mitochondrial diseases, currently reported to affect ∼1 person in 4,300, creating a large number of potential gene-environment interactions in mitochondrial toxicity. We briefly review this history, and then highlight c...
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amage to cellular mitochondria has snowballed into one of the most feared toxicities of antiretroviral therapy. Yet its incidence and prevalence among patients being treated with various nucleoside reverse transcriptase inhibitors (NRTIs)—believed to be the most likely culprits—have not been elucidated and the precise role, if any, of drug-induced mitochondrial damage in the development of hall...
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Introduction In addition to their critical role in energy generation in eukaryotic cells, mitochondria are also active participants in a variety of tissue-specific metabolic processes, like urea generation, heme synthesis, and fatty acid β oxidation. They are also structurally, electrochemically and physiologically complex. The result is that there are numerous possible mechanisms by which xeno...
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my expression of gratitude for giving me the possibility to work on a doctoral thesis in your lab. It has been very interesting to work under the guidance of such a motivating and inspiring person as you. I also would like to thank you for your support in times when everything did not turn out as planned. In the very first year of my thesis I was very fortunate to be guided by Dr. Michael Török...
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Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2018
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfy008